RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-26a-1
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
PCR; immunofluorescence etc.
Target
COLLAGEN I;CTGF
Pathway
NF-KAPPA B SIGNALING PATHWAY
PubMed ID
Title
NF-kB Mediated miR-26a Regulation in Cardiac Fibrosis
Year
2012
Function
"miR-26a has targets collagen i and CTGF and possesses putative NF-KB binding element in its promoter region, inhibition of NF-KB in cardiac fibroblast restores miR-26a expression, attenuating collagen i, and CTGF gene expression in the presence of ang ii, conferring a feedback regulatory mechanism in cardiac fibrosis."